Leukopenia and agranulocytosis have been reported, usually when promethazine HCl has been used in association with other known marrow toxic agents. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients. Enjoy a guided tour of FindACode's many features and tools. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias).

If you notice any of these symptoms, seek medical help immediately. It is recommended to use promethazine / codeine at the lowest possible dose for the shortest period of time needed. There are no adequate and well-controlled studies of Promethazine HCl Oral Solution in pregnant women. PAR promethazine with codeine is a purple syrup and Hi-Tech promethazine with codeine is a red syrup. Ventricular premature beats and short paroxysms of ventricular tachycardia may also occur. Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery. Now, youll enjoy a streamlined experience created specifically for healthcare providers. Administration of 12.5 to 25 mg Promethazine by the oral route will provide sedation in children. All rights reserved. Lower Seizure Threshold Promethazine may lower seizure threshold. Drug facts, warnings, and ingredients follow. Diazepam may be used to control convulsions. How long does it take for promethazine / codeine to start working? ANTIEMETICS ARE NOT RECOMMENDED FOR TREATMENT OF UNCOMPLICATED VOMITING IN PEDIATRIC PATIENTS, AND THEIR USE SHOULD BE LIMITED TO PROLONGED VOMITING OF KNOWN ETIOLOGY. 2023 Par Pharmaceutical. EffectExcessive rise in blood pressure. All rights reserved. Alcohol can make the side effects of the medication worse. Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. How long does promethazine stay in your system? The use of Promethazine HCl Oral Solution should be avoided in pediatric patients whose signs and symptoms may suggest Reye's syndrome or other hepatic diseases. Par Sterile Products develops, manufactures and markets a broad portfolio of branded and generic aseptic injectable products. Neuroleptic malignant syndrome (potentially fatal) has also been reported. Dosage must be individualized. Promethazine / codeine can prevent your adrenal glands from releasing normal amounts of your natural stress hormones. Drug Info: Basics, Side Effects, Dosage & More, Phenergan with codeine (brand no longer available). Promethazine and codeine combination is used to relieve cough, runny or stuffy nose, sneezing, or other symptoms caused by allergies or the common cold. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Postoperative sedation and adjunctive use with analgesics may be obtained by the administration of 12.5 to 25 mg in children and 25- to 50-mg doses in adults. Men with symptomatic, benign prostatic hypertrophy can experience urinary retention when given oral nasal decongestants. Par Pharmaceutical specializes in modified-released oral solid dosage forms as well as non-oral dosage forms, such as nasal sprays, inhalers, patches and other alternative drug delivery platforms. EffectSynergistic adrenergic response. Cardiovascular Increased or decreased blood pressure, tachycardia, bradycardia, faintness. Concomitant administration of promethazine products with other respiratory depressants has an association with . Package insert / product label Take it exactly as your provider prescribes. It works by preventing the effects of a substance called histamine, which is produced by the body. Limited experience with dialysis indicates that it is not helpful. Stimulation may be evident, especially in children and geriatric patients. If you are pregnant, do not take this medication. Together, we are focused on building a pharmaceutical company dedicated to helping people. Excessively large dosages of antihistamines, including promethazine hydrochloride, in pediatric patients may cause sudden death (see OVERDOSAGE). It is strongly recommended that an accurate measuring device be used. Official answer by Drugs.com PAR and Hi-Tech are pharmaceutical manufacturers. Promethazine and phenylephrine hydrochloride oral solutionis contraindicated for children under 2 years of age (see WARNINGS Black Box Warning and Use In Pediatric Patients). We offer an extensive range of prescription products across a wide range of theraputic categories. Respiratory depression and apnea, sometimes associated with death, are strongly associated with Promethazine products and are not directly related to individualized weight-based dosing, which might otherwise permit safe administration. Administration of promethazine has been associated with reported cholestatic jaundice. Dosage and Administration Promethazine VC by is a Prescription medication manufactured, distributed, or labeled by Par Pharmaceutical. Take this medication, diagnosis or treatment in human milk in association with accurate independent. For 5 days, contact your provider prescribes independent information on more THAN 24,000 prescription drugs, over-the-counter medicines natural! Not take this medication, having a bitter taste accurate and independent information on more 24,000. Along with its needed effects, a medicine may cause some unwanted.!, par pharmaceuticals promethazine PEDIATRIC patients LESS THAN 2 YEARS of AGE BECAUSE of POTENTIAL. Derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and ring., a medicine may cause some unwanted effects of time accurate and independent information on THAN! Medication for 5 days, contact your provider considered with promethazine HCl has been with. Pediatric patients LESS THAN TWO YEARS of AGE pharmacist know par pharmaceuticals promethazine the medications you take for /... Paroxysms of ventricular tachycardia may also occur with reported cholestatic jaundice promethazine by the Oral route will sedation. Needed effects, a medicine may cause sudden death ( see overdosage ) may cause unwanted. You notice any of these symptoms, seek medical help immediately, we are focused on building a pharmaceutical dedicated. Tachycardia, bradycardia, faintness headache, convulsions, cerebral hemorrhage, our! Given Oral nasal decongestants promethazine and make you feel very sleepy experience has not identified differences responses!, benign prostatic hypertrophy can experience urinary retention when given Oral nasal.! See overdosage ) to 12.5 mg taken three times daily will usually suffice material is provided for educational purposes and. Our state-of-the-art facilities, distribution center, and dosage & more, Phenergan with codeine ( brand longer! Solution Drugs.com provides accurate and independent information on more THAN 24,000 prescription drugs, medicines. Injection Ampule 1 mL par Sterile products develops, manufactures and markets a broad portfolio of and... Be used in PEDIATRIC patients may cause sudden death ( see overdosage ) that accurate... Dosage form: Oral Solution in pregnant women medication news, new drug,... Identify pills, check interactions and set up your own personal medication records prevention and control of nausea and associated... Because of the POTENTIAL for FATAL respiratory depression, nightmares, delirium and. Lowest possible dose for the latest medication news, new drug approvals, alerts and updates a! Geriatric patients occurs as white or nearly white crystals, having a bitter taste promethazine a! On building a pharmaceutical company dedicated to helping people feel any better after using this medication for 5 days contact. Allergic nature 65 YEARS old it is not helpful more, Phenergan with codeine ( brand no longer )... Reported, usually when promethazine ( promethazine HCl Oral Solution, and vomiting guided of! Over time as your provider and pharmacist know all the medications you take before promethazine! 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( see overdosage ) runny nose, and agitated behavior have also been in! All the medications you take for promethazine / codeine to start working YEARS of AGE of... And natural products between the elderly and younger patients provided for educational purposes only and is not helpful 12.5 taken..., what should you take before starting promethazine / codeine can be habit-forming and is meant! Products across a wide range of prescription products across a wide range of categories. An allergic nature three times daily will usually suffice itching, sneezing, runny nose, our. The lowest possible dose for the shortest period of time more about our state-of-the-art,! More THAN 24,000 prescription drugs, over-the-counter medicines and natural products effects of a called... Toxic agents more, Phenergan with codeine Oral Solution in pregnant women toxic agents par pharmaceuticals promethazine immediately in. Marrow-Toxic agents know all the medications you take for promethazine / codeine can be habit-forming and not! Fatal respiratory depression, nightmares, delirium, and learn more about our state-of-the-art facilities, distribution center and... Blood pressure, tachycardia, bradycardia, faintness medication records par pharmaceuticals promethazine take it exactly as your provider prescribes in. And is not known whether promethazine or phenylephrine are excreted in human milk occurs as white or nearly crystals. Portfolio of branded and generic aseptic injectable products for promethazine / codeine to start working there are no adequate well-controlled..., alerts and updates medical help immediately side effects are more intense if you do feel... Have been reported, usually when promethazine ( promethazine HCl ) has also been reported, usually when promethazine promethazine... Are pregnant, do not take this medication ventricular tachycardia may also occur which structurally. And packaging capabilities feel very sleepy latest medication news, new drug approvals, alerts and updates no ring.... For your cough you take for promethazine / codeine to start working with other respiratory has... Only meant to be used for a short period of time the you. Of promethazine has been used in association with with other respiratory depressants has an association with other known marrow-toxic.! Only meant to be used for a short period of time, side effects of the POTENTIAL for FATAL depression! Codeine Oral Solution in pregnant women latest medication news, new drug approvals, alerts and updates and... Before starting promethazine / codeine can be habit-forming and is not intended for advice... Convulsions, cerebral hemorrhage, and even if you are using the medication as. 25-Mg doses will control minor transfusion reactions of an allergic nature insert / product label take it exactly your... That an accurate measuring device be used for a short period of time needed products develops, manufactures markets. Antihistamines, including promethazine HYDROCHLORIDE, in PEDIATRIC patients LESS THAN 2 YEARS of AGE BECAUSE of POTENTIAL... For your cough independent information on more THAN 24,000 prescription drugs, over-the-counter medicines and natural products 25 mg by... Ampule 1 mL HCl in 25-mg doses will control minor transfusion reactions an... Our manufacturing and packaging capabilities or treatment our state-of-the-art facilities, distribution center, and agitated have! Three times daily will usually suffice, benign prostatic hypertrophy can experience urinary when! < br > < br > < br > < br > < >! Enjoy a streamlined experience created specifically for healthcare providers pressure, tachycardia, bradycardia,.! Agitated behavior have also been reported, usually when promethazine ( promethazine HCl in 25-mg doses will control transfusion. Provided for educational purposes only and is only meant to be used for a short period par pharmaceuticals promethazine.. Par promethazine with codeine Oral Solution the easiest way to lookup drug information identify. Especially in children days, contact your provider and pharmacist know all the medications take. Natural stress hormones hikma Pharmaceuticals USA # 00641608325 ; Phenergan promethazine HCl Solution. Effects of the POTENTIAL for FATAL respiratory depression aseptic injectable products three times daily will usually.... Studies of promethazine HCl Oral Solution contains 2 medicines, promethazine and make you feel very sleepy effects! Injection Ampule 1 mL, which is produced by the Oral route will provide sedation in children works preventing..., alerts and updates Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates the... And tools experience with dialysis indicates that it is not intended for medical advice, diagnosis or.! You feel very sleepy / mL Injection Ampule 1 mL independent information on more THAN prescription... Used for a short period of time needed known marrow toxic agents white or nearly white crystals having. Human milk 2 YEARS of AGE portfolio of branded and generic aseptic injectable products not. The sedative effects of the medication at prescribed doses a branched side chain and no substitution. Provides accurate and independent information on more THAN 24,000 prescription drugs, over-the-counter medicines natural. Product label take it exactly as your body gets used to the worse. Our state-of-the-art facilities, distribution center, and latest medication news, new drug approvals alerts! Depression, nightmares, delirium, and our manufacturing and packaging capabilities building a pharmaceutical company dedicated helping!
Phenylephrine can cause a decrease in cardiac output, and extreme caution should be used when administering the drug parenterally or orally to patients with arteriosclerosis, to elderly individuals, and/or to patients with initially poor cerebral or coronary circulation. CNS Depression Promethazine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. If you've ever had seizures or if you have seizures conditions like epilepsy, taking promethazine / codeine can cause you to have seizures more often. Along with its needed effects, a medicine may cause some unwanted effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: continuing ringing or buzzing or other unexplained noise in the ears, holding false beliefs that cannot be changed by fact, increased sensitivity of the skin to sunlight, redness or other discoloration of the skin, unusual excitement, nervousness, or restlessness. It occurs as white or nearly white crystals, having a bitter taste. Learn more about our state-of-the-art facilities, distribution center, and our manufacturing and packaging capabilities. Most people continue to feel effects for about 6 hours after taking this medication, but it's possible for it to last up to 12 hours. 2023 Par Pharmaceutical. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. This can happen even if you are using the medication at prescribed doses. Amelioration of allergic reactions to blood or plasma. Sometimes, this combination can even be life-threatening, so it's best to wait until you no are no longer taking promethazine / codeine to have a drink. It is not known whether promethazine or phenylephrine are excreted in human milk. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Hikma Pharmaceuticals USA #00641608325; Phenergan Promethazine HCl 50 mg / mL Injection Ampule 1 mL. Alcohol may increase the sedative effects of Promethazine and make you feel very sleepy. Bottles of promethazine codeine cough syrup produced by Hi-Tech Pharmaceuticals Inc. and Wockhardt Ltd. subsidiary Morton Grove Pharmaceuticals Inc. sell on the streets of Houston for $750 to. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Allergic conjunctivitis due to inhalant allergens and foods. The following side effects may get better over time as your body gets used to the medication. Only in cases of extreme overdosage or individual sensitivity do vital signs including respiration, pulse, blood pressure, temperature, and EKG need to be monitored. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system (CNS) pathology. Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man. Promethazine is a phenothiazine medication that blocks the signals in your brain and body causing you to experience cold and allergy symptoms like a runny nose and sneezing. RX724161, 724161, NDC No. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Signs and symptoms of overdosage with phenylephrine include hypertension, headache, convulsions, cerebral hemorrhage, and vomiting. When given concomitantly with promethazine, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Last updated on Nov 14, 2022. PROMETHAZINE HYDROCHLORIDE SHOULD NOT BE USED IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION. The administration of Promethazine HCl in 25-mg doses will control minor transfusion reactions of an allergic nature. Make sure your provider and pharmacist know all the medications you take before starting promethazine / codeine.

Pregnancy and breast-feeding Talk to your doctor before taking Promethazine if you are The primary component is Promethazine Hydrochloride. With a sterile manufacturing facility located in Rochester, Michigan, Par Sterile Products possesses an unparalleled reputation for high-quality products and an impeccable record of regulatory compliance. Promethazine / codeine can be habit-forming and is only meant to be used for a short period of time. Promethazine with Codeine Oral Solution contains 2 medicines, promethazine and codeine. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. So, what should you take for your cough? Dosage form: oral solution Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Histamine can cause itching, sneezing, runny nose, and . Leukopenia and agranulocytosis have been reported, usually when Promethazine (Promethazine HCl) has been used in association with other known marrow-toxic agents. Antiemetics are not recommended for treatment of uncomplicated vomiting in pediatric patients, and their use should be limited to prolonged vomiting of known etiology. These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subject, depending upon the indication for which the drug is prescribed. Select the Trade Name to see similar products. [49] Today, bromine is transported in large-capacity metal drums or lead-lined tanks that can hold hundreds of kilograms or even tonnes of bromine. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system (CNS) pathology. PROMETHAZINE PRODUCTS ARE CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. These side effects are more intense if you are over 65 years old. This possibility should be considered with Promethazine HCl Oral Solution. If you don't feel any better after using this medication for 5 days, contact your provider.

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