A 2015 report published in the Journal of Lipidsshowed that bitter melon hasmetabolism-boosting effects: Proinflammatory cytokines and oxidative stress have been shown to be responsible for developing metabolic disturbances, such as insulin resistance and activation of immune response in liver, adipose tissue, and muscles. They began cooking and using the fruit in recipes, as well as juicing it to create a tonic in order to help treat such conditions as indigestion, an upset stomach, skin wounds, chronic coughs and respiratory infections. J Ethnopharmacol. (2), Although researchers state thatfurther studies are required to recommend its use for certain conditions, according to a 2004 review published in the Journal of Ethnopharmacology, findings show that bitter melon has some of the following benefits: (3). It has a very long history of use in China, Ayurvedic medicine a traditional system of healing that has been practiced for India for over 3,000 years and also in some of the healthiest places of the world, such asOkinawa, Japan (one of the worlds blue zones). How to Boost Your SOD Production Naturally When the SOD enzyme was discovered, many researchers rushed to create a supplement that could be taken orally to boost our bodys production of SOD. J Eur Acad Dermatol Venereol 2021;35(8):1725-9. J Pediatr 1984;105:781-5.

Superoxide dismutase (SOD, orgotein) is an ubiquitous enzyme that has received attention because of its therapeutic activity and because of claims that its ingestion may improve health and lengthen the human lifespan. Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction. Injecting superoxide dismutase into the joint might help reduce pain and stiffness in people with RA. Lee-Huang S, Huang PL, Chen HC, et al. Giving superoxide dismutase by IV doesn't seem to help to reduce. 2015;14:13. Astrong immune system and well-functioning digestive system are essential for fending off potential infections and diseases, as well as reducing seasonal allergies and asthma. Bitter melon might lower blood sugar levels. Leung SO, Yeung HW, Leung KN. Several investigational reports suggest that bitter melon can reduce body weight in high fat diet induced obesity in laboratory animals. 2018;21(7):672-7. doi: 10.1089/jmf.2017.0114. Anila L, Vijayalakshmi NR. There also isnt enough evidence to recommend SOD for women who are pregnant or breastfeeding, so people in these circumstances should use caution unless advised otherwise by their health care professionals. This is often referred to as oxidative stress, and it occurs when the balance of antioxidants and free radicals in the body is disturbed. Kadrnka F. [Results of a multicenter orgotein study in radiation induced and interstitial cystitis]. Furthermore, it protects the leucocytes themselves from free radical damage. View abstract. Anthemintics work by killing parasites internally, without causing significant damage to the host (the person or animal carrying the parasite). The data showed that bitter melon extract (1 g/kg) significantly lowered the blood glucose level of both normal and diabetic mice. Its important to consult with your health care professional before using SOD supplements to improve symptoms of any medical condition. Learn more about our ingredient Bertolotto F., Massone A. Bitter melon can cause side effects and interfere with other medications. 1986;15(1):107-117. View abstract. Immunopharmacol 1987;13:159-71. View abstract. Several studies have identified anti-inflammatory compounds within bitter melon that help treat skin conditions such as eczema and psoriasis. SOD B is the unique source of bioactive melon SOD worldwide. Its alsoa popular addition to stir-fries in China, India and Japan and promoted for its digestive-boosting benefits. SOD is obtained for clinical use through genetically engineered biotechnology sources. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. View abstract. However, oxidative stress can occur and induce muscular damages. The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. WebSide Effects The main complaint seems to be pain at the injection site. These include gallic acid, tannic acid, catechin, caffeic acid, p-coumaric, gentisic acid, chlorogenic acid and epicatechin. J Fam.Pract. Background: Recent studies have demonstrated a correlation between perceived stress and oxidative stress. Background: Recent studies have demonstrated a correlation between perceived stress and oxidative stress. WebExtramel efficacy has been demonstrated in 2 clinical studies (randomized, double-blind, placebo-controlled) in a total of 130 subjects. Since the superoxide radical is toxic to normal living cells, the enzyme superoxide dismutase, which is present in all cells, catalyzes the conversion of superoxide to the harmless components oxygen and hydrogen peroxide. Shekelle, P. G., Hardy, M., Morton, S. C., Coulter, I., Venuturupalli, S., Favreau, J., and Hilton, L. K. Are Ayurvedic herbs for diabetes effective? Br J Pharmacol 2006;148(8):1156-1164. 2019;157:21-7. doi: 10.1016/j.phytochem.2018.10.009. Improvements in their health without any side effects were observed PROVIDING EXCEPTIONAL PROTECTION AGAINST FREE RADICAL DAMAGE Helps raise antioxidant defense levels and may protect DNA from oxidative With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Some of the risks and complications of bitter melon include: diarrhea , vomiting, and other intestinal issues Circulation 1994;89:1982-91. de Benito V, de Barrio M, de Lopez-Saez MP, et al. Studies today show that bitter melon juice, fruit and seeds can be beneficial for preventing respiratory illnesses, coughs, mucus andfood allergies. In West Germany, where orgotein has been in general medical use for years, the drug is injected locally for the management of osteoarthritis, sports injuries, and knee joint osteoarthritis. J Nutr 2005;135(4):702-706. Complement Ther Med. Lloydia 1974;37(4):645. Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Like superoxide dismutase, catalase is an antioxidant enzyme that removes hydrogen peroxide from the body by converting it into water and oxygen. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. These include: steroidal saponins (knownas charantins), insulin-like peptides and alkaloids, which are most heavilyconcentrated in fruit of theMomordica charantia plant. Superoxide dismutase creams and other personal care products are used to reduce free radical damage to the skin and lower signs of aging. These oral supplements have been said to remove wrinkles and age lines, slow the aging process, and facilitate a longer, healthier life. The women received SOD or placebo for 56 consecutive days. WebSide Effects Precautions Interactions Dosing Reviews (37) Overview Bitter melon (Momordica charantia) is a vine originally from India and other Asian countries. WebExtramel is a melon juice concentrate containing 14,000 IU/g of superoxide dismutase (SOD) activity (140 IU per 10 mg serving) from the 3 different SOD isoforms found in plants: Fe-SOD, Cu,Zn-SOD and Mn-SOD. View abstract. Guaranteed bioactivity Thanks to a micro-encapsulation, Extramel activity is protected from acid attacks and aqueous media. Medicine (Baltimore) 2021;100(27):e26606. View abstract. 2015;2015:496169. Olive leaf extract may cause side effects, including coughing, vertigo, muscle discomfort, headache, muscle cramp, fatigue, and malaise. Planta Med 1990;56:426-9. WebExtramel, an ingredient rich in SOD, a natural solution for stress relief. Dixit, V. P., Khanna, P., and Bhargava, S. K. Effects of Momordica charantia L. fruit extract on the testicular function of dog. Based on research thats available at this time, bitter melon is meant to be used in conjunction with other preventive measures (like eating a healthy diet and exercising to control inflammation), along with conventional treatments when necessary. Am J Health Syst Pharm 2003;60:356-9. Select a condition to view a list of vitamins. J Immunol Res. (6) Research done at Annamali University in India showed that extract from bitter melonincreased levels of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase, helping to improve detoxification and prevent liver damage. Benefits include increasing immunity, lowering diabetes symptoms, fighting free radical damage and inflammation, treating skin problems, improving digestion and helping to prevent cancer. J Nutr Sci Vitaminol. View abstract. Broadley MR, White PJ. Toxicology SOD has been recognized as a remarkably nontoxic compound. WebExtramel, an ingredient rich in SOD, a natural solution for stress relief. (. Insulin resistance and high blood sugar levels, Eye disorders such as cataracts or glaucoma, Hormonal irregularities and menstrual changes in women, Heart complications and blood vessel damage. (8), While more research is still needed, to date a small group of studies have found that cancer patients using bitter melon in addition to other treatments have shown promising results. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. J Ethnopharmacol 1986;17:277-82. For the most accurate information on how to use SOD supplements, seek advice from your health care provider. How to Boost Your SOD Production Naturally When the SOD enzyme was discovered, many researchers rushed to create a supplement that could be taken orally to boost our bodys production of SOD. Lee-Huang S, Huang PL, Nara PL, et al. Improvements in their health without any side effects were observed PROVIDING EXCEPTIONAL PROTECTION AGAINST FREE RADICAL DAMAGE Helps raise antioxidant defense levels and may protect DNA from oxidative View abstract. Phytomedicine 1996;2(4):349-362. In fact, this powerful enzyme forms the front line of defense against reactive oxygen species that lead to cellular damage within the body. View abstract. Kohno, H., Yasui, Y., Suzuki, R., Hosokawa, M., Miyashita, K., and Tanaka, T. Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition. Schreiber CA, Wan L, Sun Y, et al. In India, bitter melon is considered one of the mostimportant plants for Ayurvedic ethnobotanical practices. In Ayurveda, the fruit has been used to help balance hormones, manage symptoms of diabetes, reduce digestive upset, treat skin disorders or wounds, and also as a natural laxative for treating constipation. For instance, oxidative skin damage as a result of ultraviolet (UV) exposure can be ameliorated by SODgliadin treatment. Baldwa VS, Bhandara CM, Pangaria A, and et al. J Ethnopharmacol. Vicine, a favism-inducing toxin from Momordica charantia Linn. An enzyme is a substance that speeds up certain chemical reactions in the body. Dietary supplementation with a superoxide dismutase-melon concentrate reduces stress, physical and mental fatigue in healthy people: a randomised, double-blind, placebo-controlled trial. Potential biomarkers of peripheral and central fatigue in high-intensity trained athletes at high-temperature: a pilot study with Momordica charantia (bitter melon). Prep.Biochem 1982;12(4):355-375. Gammer W, Broback LG. WebAfter 12 weeks of oral administration, Extramel((R)) lowered plasma cholesterol and non-HDL cholesterol and induced blood and liver SOD activities. A report on allergic reactions and lack of radioprotective effect. Recent research shows that theres a significant association of low extracellular superoxide dismutase expression with reduced cancer patient survival. Nielsen OS, Overgaard J, Overgaard M, et al. Bae W, Kim S, Choi J, et al. While this melon has proven hypoglycemiceffects, available scientific data is not sufficientto recommend its use for treating diabetes withoutcareful supervision and monitoring. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Polysaccharides from fermented Momordica charantia ameliorate obesity in high-fat induced obese rats. SOD B M is a melon concentrate, well known to counteract oxidative stress and prevent its side effects. Since, scientists have formulated newer supplements that are meant to be bioavailable because the enzyme is combined with protective proteins that are derived from wheat and other plants.

May Hamper Sugar levels Diabetes mellitus is a condition characterised by elevated blood sugar (glucose) levels. Efficacy and safety of the combination of superoxide dismutase, alpha lipoic acid, vitamin B12, and carnitine for 12 months in patients with diabetic neuropathy. Superoxide has been successfully used to treat human inflammatory diseases. View abstract. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Guaranteed bioactivity Thanks to a micro-encapsulation, Extramel activity is protected from acid attacks and aqueous media. Phytother Res 1993;7:285-289. Induction of tumor cytotoxic immune cells using a protein from the bitter melon (Momordica charantia). References 1. J Med Food. WebExtramel efficacy has been demonstrated in 2 clinical studies (randomized, double-blind, placebo-controlled) in a total of 130 subjects. 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Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 4 Apr 2023), ASHP (updated 12 Mar 2023) and others. Here are some reasons why you must look out for your portion of melons in a day. Orgotein in radiation treatment of bladder cancer. Some researchers have expressed concern about the risks of consuming SOD supplements made from animal sources because the animal may be sick or diseased. WebAfter 12 weeks of oral administration, Extramel((R)) lowered plasma cholesterol and non-HDL cholesterol and induced blood and liver SOD activities.

The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies. View abstract. Liu, H. L., Wan, X., Huang, X. F., and Kong, L. Y. Biotransformation of sinapic acid catalyzed by Momordica charantia peroxidase. White blood cells involved in the acute inflammatory response release large amounts of superoxide, which appears to contribute to the destruction of bacteria. Chan, W. Y., Tam, P. P., and Yeung, H. W. The termination of early pregnancy in the mouse by beta-momorcharin. Yin RV, Lee NC, Hirpara H, Phung OJ. However, oxidative stress can occur and induce muscular damages. Walravens M, Dequeker J. There is a single clinical trial in which SOD was administered intratracheally in premature infants. 2018;40(7):1400-1405. View abstract. Information regarding safety and efficacy in pregnancy and lactation is lacking. View abstract. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Our complete range of coating fits all your projects. Olive leaf extract may cause side effects, including coughing, vertigo, muscle discomfort, headache, muscle cramp, fatigue, and malaise. If adding antioxidant foods to your diet isnt enough and you are using SOD to fight a particular health condition, supplements and IV doses are available. Look for immature melon fruit that is green, firm and free from bruising or splitting. Bitter melon (Momordica charantia) is a type of edible, medicinal fruit that is native to Asia, Africa and parts ofthe Caribbean. Scand J Rheumatol 1984;13:108-12. These agents are capable of lowering susceptibility to such infections as Helicobacter pylori (a very common bacteria tied to the formation of stomach ulcers when someones immune function is low), along with viruses including HIV. View abstract. 5 Side Effects of Melons1. WebAfter 12 weeks of oral administration, Extramel((R)) lowered plasma cholesterol and non-HDL cholesterol and induced blood and liver SOD activities. Flaherty JT, Pitt B, Gruber JW, et al. Between 1,0002,000 milligrams of this melon extract daily (split into 23 dosages) is usually recommended for treating most conditions, although bitter melon should be avoided by pregnant women, those taking diabetic medications, and people recovering from surgery. Its important to consult with your health care professional before using SOD supplements to improve symptoms of any medical condition. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Superoxide dismutase is an antioxidant enzyme thats found in all living cells within the body. View abstract. In Turkish folk medicine, bitter melon is known as a stomach soother, despite its strong, sometimes off-putting taste. The appropriate superoxide dismutase dosage depends on your health condition, age and gender. Contraindications have not yet been identified. SOD represents 85 to 90% of the total antioxidant capacity of SOD B .As a concentrate, SOD B is not 2019;10(1):448-57. doi: 10.1039/c8fo01609g. Among the many benefits associated with it, SOD contributes in particular to the management of daily stress, thanks to an action directly on the physiological response of the body. WebExtramel, an ingredient rich in SOD, a natural solution for stress relief. Available at: www.cfsan.fda.gov/~dms/dspltr05.html. SOD generally protects the fluid against this degradation. (4), It did so primarily by regulating the insulin signaling pathways in muscles and fat cells (adipose tissues), helping cells to take up more glucose from the blood as needed. Planta Med 1978;34(3):280-286. Lewis CJ. 2000;9(1):138-144. Takemoto, D. J., Jilka, C., and Kresie, R. Purification and characterization of a cytostatic factor from the bitter melon Momordica charantia. Macrobiotic Nutritionist and Health Practitioner Shilpa Arora says, excess of melons may not be the best of idea for diabetics. View abstract. This visible improvement was observed in 71% of Landeen KC, Spanos WC, Gromer L. Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer. From the seeds of the bitter gourd Momordica charantia (Family Cucurbitaceae). Lecithin-bound superoxide dismutase in the treatment of noninfectious corneal ulcers. The beneficial effects of dietary melon SOD combined with gliadin in other health-related areas also have been considered. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Grover JK, Vats V, Rathi SS, Dawar R. Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. Our complete range of coating fits all your projects. View abstract. Anti-HIV and anti-tumor activities of recombinant MAP30 from bitter melon. Taking bitter melon along with diabetes medications might cause blood sugar to drop too low. WebExtramel is a melon juice concentrate containing 14,000 IU/g of superoxide dismutase (SOD) activity (140 IU per 10 mg serving) from the 3 different SOD isoforms found in plants: Fe-SOD, Cu,Zn-SOD and Mn-SOD. A report printed in the International Journal of Microbiology states thatpowdered bitter melon has been used in Ayurveda for centuries for dusting over leprous and other intractable ulcers and in healing wounds, especially when mixed with cinnamon, long pepper, rice, and chaulmugra oil. In recent years, bitter melon extract has been successfully used against pylorus ligation, aspirin and stress-induced ulcers in rats, showing significant reductions in ulcer symptoms. 2017;7(1):e241. Prevention of radioinduced cystitis by orgotein: a randomized study. A randomized double-blind trial of the use of human recombinant superoxide dismutase in renal transplantation. are clickable links to medically peer-reviewed studies. View abstract. View abstract. WebSide Effects Precautions Interactions Dosing Reviews (37) Overview Bitter melon (Momordica charantia) is a vine originally from India and other Asian countries. Bangladesh Med Res Counc Bull 1999;25:11-3. Learn more about our ingredient Injection of SOD in 8 to 32 mg doses has been reported. View abstract. Nutr Diabetes. Bitter melon can cause side effects and interfere with other medications. View abstract. SOD represents 85 to 90% of the total antioxidant capacity of SOD B .As a concentrate, SOD B is not These forms of the antioxidant enzyme are distributed throughout the body in different subcellular compartments. View abstract. There are no published data to support these claims. Some data indicate that longer-lived animal species have a higher internal degree of protection against free radicals. Food Funct. More about sod Professional resources Advanced View abstract. Bitter melon is usually taken in doses of 12 capsules, three times a day after meals, for up to 3 months. What foods contain superoxide dismutase? Although study results have been inconsistent, several studies have demonstrated bitter melons efficacy in preventing or managing various types of cancers: lymphoid leukemia, lymphoma, choriocarcinoma, melanoma, breast cancer, skin tumor, prostatic cancer, carcinoma of the tongue and larynx, bladder cancer and Hodgkins disease. Theres evidence that bitter melon extract can help reduce stomach and intestinal disorders, decrease kidney stones, help prevent liver disease and improve liver function, help treat parasitic worms that enter the GI tract, reduce symptoms of inflammatory bowel disease (including colitis) and improve overall digestive health. AIDS Asia 1995;2(4):6-7. McIlwain H, Silverfield JC, Cheatum DE, et al. View abstract. Information from this source is evidence-based and objective, and without commercial influence. Senanayake, G. V., Maruyama, M., Sakono, M., Fukuda, N., Morishita, T., Yukizaki, C., Kawano, M., and Ohta, H. The effects of bitter melon (Momordica charantia) extracts on serum and liver lipid parameters in hamsters fed cholesterol-free and cholesterol-enriched diets. View abstract. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff.
The effects of Momordica charantia (bitter melon) supplementation in patients with primary knee osteoarthritis: A single-blinded, randomized controlled trial. Am J Ophthalmol 2003;135:613-9. 1985;13(3):313-321. (12). Recently, it has even been discovered that it can help actagainst Helicobacter pylori bacteria that contributes to ulcer formation. Jiratchariyakul W, Wiwat C, Vongsakul M, et al. Biochem Biophys Res Commun 1995;208:779-85. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes.

Macrobiotic Nutritionist and Health Practitioner Shilpa Arora says, excess of melons may not be the best of idea for diabetics. Its SOD B Dimpless dry melon juice significantly reduced cellulite in the randomised, double blind, placebo-controlled study with 41 healthy women with cellulite between the ages of 31 and 50, with a Body Mass Index (BMI) of 23-30. More about sod Professional resources Advanced For instance, oxidative skin damage as a result of ultraviolet (UV) exposure can be ameliorated by SODgliadin treatment. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. Avoid use. WebHighest SOD activity. It can be consumed raw, cooked or extract and tablet form. 2003;86(1):61-68. Available for Android and iOS devices. Nutr Diabetes. In immature vegetable form, bitter melon is also a good source of nutrients including. View abstract. Bitter melon (Momordica charantia) is a vine originally from India and other Asian countries. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

The fruit has been used in healing systems native to places such as India, Indonesia, Turkey, Japan and Turkey for at least 700 years! You can also find SOD supplements, and it can be used intravenously by a health care professional. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Bitter melon was shown to target insulin receptor sites and stimulate downstream pathways, leading researchers to conclude it can serve as a beneficial regulator of glucose metabolism.. 2015;46(4):1849-57. Available from Wolters Kluwer Health, Inc. Accessed April 23, 2007. Clinical comparison of orgotein and methylprednisolone acetate in the treatment of osteoarthrosis of the knee joint. Some mild side effects that have been reported after SOD intravenous administration are pain and irritation at the injection site. Int J Peptide Protein Res 1986;28(2):163-172. Cakici I, Hurmoglu C, Tunctan B, et al. J Clin Biochem Nutr. Hypoglycaemic effect of Momordica charantia extracts in normoglycaemic or cyproheptadine-induced hyperglycaemic mice. Phytother Res 2000;14:592-5. Wang, Y. X., Neamati, N., Jacob, J., Palmer, I., Stahl, S. J., Kaufman, J. D., Huang, P. L., Huang, P. L., Winslow, H. E., Pommier, Y., Wingfield, P. T., Lee-Huang, S., Bax, A., and Torchia, D. A. Look for pure bitter melon extract in tablet or capsule form that is ideally certified organic, Non-GMO Project Verified, gluten-free, magnesium stearate free, and contains no synthetic additives. Somasagara RR, Deep G, Shrotriya S, Patel M, Agarwal C, Agarwal R. Bitter melon juice targets molecular mechanisms underlying gemcitabine resistance in pancreatic cancer cells. 2004;143(3):379-87. View abstract. Toxicology SOD has been recognized as a remarkably nontoxic compound. Leatherdale B, Panesar RK, Singh G, et al. Pregnant women, those who are trying to become pregnant, and women who are breastfeeding should not consume bitter melon, since research shows that it has someabortifacient properties (those that can cause miscarriages), can cause menstrual bleeding, and has certain anti-fertility capabilities. Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. WebSOD B Dimpless induces a significant visual reduction of cellulite on thighs by 9.5 % and 11.3 % compared to the placebo, respectively after 28 and 56 days of oral supplementation at 40 mg/day (480 IU SOD). May Hamper Sugar levels Diabetes mellitus is a condition characterised by elevated blood sugar (glucose) levels. Anticancer Res 2000;20(2A):653-659. Drugs R D 2012;12(1):29-34. Our team aims to be not only thorough with its research, but also objective and unbiased. Guaranteed bioactivity Thanks to a micro-encapsulation, Extramel activity is protected from acid attacks and aqueous media. WebWELL-TOLERATED WITH NO SIDE EFFECTS Sixteen people were supplemented with GliSODin in a 2-year clinical study.

Naseem MZ, Patil SR, Patil SR, et al. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). View abstract. Fertil Steril 1999;72:686-90. Bitter melon has been the focus of well over 100 clinical and observational studies.

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